Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

S-Adenosylmethionine.

S C Lu1

  • 1Division of Gastroenterology and Liver Diseases, USC Liver Disease Research Center, USC School of Medicine, Los Angeles, CA 90033, USA. shellylu@hsc.usc.edu

The International Journal of Biochemistry & Cell Biology
|April 13, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Sequential surgery following conversion therapy based on the combination of immune checkpoint inhibitors and antiangiogenic targeted drugs alters the treatment landscape and outcomes for advanced hepatocellular carcinoma].

Zhonghua yi xue za zhi·2026
Same author

[Efficacy and safety of combined immunotherapy and targeted therapy as adjuvant treatment for hepatocellular carcinoma with microvascular invasion after surgery].

Zhonghua yi xue za zhi·2026
Same author

Metabolomic-based aging clocks.

npj metabolic health and disease·2025
Same author

Development and validation of a liquid chromatography-mass spectrometry method for free monosaccharide analysis in milk from 8 species.

Journal of dairy science·2025
Same author

Correction: Introduction and validation of the open symptom framework: a public domain modular framework for patient-reported measurement of symptoms related to cancer and its treatment.

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2024
Same author

Introduction and validation of the open symptom framework: a public domain modular framework for patient-reported measurement of symptoms related to cancer and its treatment.

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2024
Same journal

Corrigendum to "Sodium butyrate down-regulation of indoleamine 2, 3-dioxygenase at the transcriptional and post-transcriptional levels" [Int. J. Biochem. Cell Biol. 42 (2010) 1840-1846].

The international journal of biochemistry & cell biology·2026
Same journal

Whole-brain spatial metabolomics reveals metabolic gradient shifts in a murine glioma model following boron neutron capture therapy (130 characters).

The international journal of biochemistry & cell biology·2026
Same journal

LCN2 modulates Th17/Treg balance in vitro and is associated with an adaptive response to intestinal ischemia-reperfusion injury under Hmox1-deficient conditions.

The international journal of biochemistry & cell biology·2026
Same journal

Chloroquine modulates the redox-sensitive signalling via inhibiting the AMPK-ULK1 under LPS induced state in murine splenic macrophages.

The international journal of biochemistry & cell biology·2026
Same journal

The vicious cycle of hyperglycemia and oxidative stress: Novel mechanistic insights into a pathogenic alliance.

The international journal of biochemistry & cell biology·2026
Same journal

Fibroblast growth factors (FGF) in the pathogenesis and treatment of inflammatory bowel diseases (IBD): An overview.

The international journal of biochemistry & cell biology·2026
See all related articles

S-Adenosyl-Lmethionine (SAM) is vital for cell survival, supporting key pathways like transmethylation and transsulfuration. Its role in cellular processes makes SAM a potential therapeutic agent for various clinical disorders.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Metabolic Pathways

Background:

  • S-Adenosyl-Lmethionine (SAM) is a crucial endogenous molecule essential for normal cellular function and survival.
  • SAM participates in three primary metabolic pathways: transmethylation, transsulfuration, and polyamine synthesis.
  • Dysregulation of SAM-dependent pathways can impact fundamental cellular processes, including gene expression, membrane integrity, and antioxidant defense.

Purpose of the Study:

  • To elucidate the fundamental roles of S-Adenosyl-Lmethionine (SAM) in cellular metabolism and function.
  • To highlight the significance of SAM in key biochemical pathways.
  • To underscore the therapeutic potential of SAM in clinical settings.

Main Methods:

  • Literature review of biochemical and cellular studies on S-Adenosyl-Lmethionine (SAM).

Related Experiment Videos

  • Analysis of SAM's involvement in transmethylation, transsulfuration, and polyamine synthesis pathways.
  • Examination of existing research on SAM's therapeutic applications.

    • Main Results:

    • SAM serves as the primary methyl group donor in transmethylation reactions, affecting DNA, proteins, and phospholipids.
    • The transsulfuration pathway utilizes SAM to produce cysteine, a precursor for glutathione, a critical antioxidant.
    • SAM is indispensable for polyamine synthesis, which is vital for cell growth and proliferation.

    Conclusions:

    • S-Adenosyl-Lmethionine (SAM) plays a multifaceted role in cellular health through its involvement in critical metabolic pathways.
    • The diverse functions of SAM, from epigenetic regulation to antioxidant defense, highlight its importance in maintaining tissue homeostasis.
    • The established biological significance of SAM supports ongoing investigations into its therapeutic utility for a range of clinical conditions.