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A common regulator for the operons encoding the enzymes involved in D-galactarate, D-glucarate, and D-glycerate
R Monterrubio1, L Baldoma, N Obradors
1Department of Biochemistry, Faculty of Pharmacy, University of Barcelona, 08028 Barcelona, Spain.
Journal of Bacteriology
|April 13, 2000
Abstract:
Genes for D-galactarate (gar) and D-glucarate (gud) metabolism in Escherichia coli are organized in three transcriptional units: garD, garPLRK, and gudPD. Two observations suggested a common regulator for the three operons. (i) Their expression was triggered by D-galactarate, D-glucarate, and D-glycerate. (ii) Metabolism of the three compounds was impaired by a single Tn5 insertion mapped in the yaeG gene (proposed name, sdaR), outside the D-galactarate and D-glucarate systems. Expression of the sdaR gene is autogenously regulated.