Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Trk B signalling controls LTP but not LTD expression in the developing rat visual cortex.

E Sermasi1, E Margotti, A Cattaneo

  • 1International School for Advanced Studies (SISSA), Neuroscience Programme, Via Beirut 2-4, 34014 Trieste, Italy.

The European Journal of Neuroscience
|April 13, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Understanding, predicting, and treating depression in pregnancy to improve mothers' and offspring's mental health outcomes: The HappyMums study.

Brain, behavior, & immunity - health·2025
Same author

Preliminary observations on tear film interferometry performed in horses.

Journal of equine veterinary science·2024
Same author

Serum concentration-guided intravenous magnesium sulfate administration for neuroprotection in patients with aneurysmal subarachnoid hemorrhage: a retrospective evaluation of a 12-year single-center experience.

Neurosurgical review·2023
Same author

Author Correction: Enteric α-synuclein impairs intestinal epithelial barrier through caspase-1-inflammasome signaling in Parkinson's disease before brain pathology.

NPJ Parkinson's disease·2023
Same author

Exposure to chronic stress impairs the ability to cope with an acute challenge: Modulation by lurasidone treatment.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology·2022
Same author

Efficacy and safety of robotic-assisted surgery in challenging hysterectomies - a single institutional experience.

European review for medical and pharmacological sciences·2022

Endogenous Trk B activation is crucial for maintaining long-term potentiation (LTP) in the developing visual cortex, but not for long-term depression (LTD). This highlights Trk B

Area of Science:

  • Neuroscience
  • Developmental Neurobiology
  • Synaptic Plasticity

Background:

  • Neurotrophins, particularly Trk B ligands, are implicated in synaptic plasticity and the development of neural connectivity, such as ocular dominance columns in the visual cortex.
  • Understanding the role of endogenous Trk B signaling is vital for comprehending the mechanisms governing synaptic development and plasticity during critical postnatal periods.

Purpose of the Study:

  • To investigate the contribution of endogenous Trk B receptor activation to synaptic plasticity, specifically long-term potentiation (LTP) and long-term depression (LTD), in the developing rat visual cortex.
  • To determine if Trk B signaling is required for the maintenance of LTP and LTP after LTD at different postnatal developmental stages (P17 and P23).

Main Methods:

  • Utilized rat cortical slices incubated with a soluble form of the Trk B receptor (TrkB IgG) to block endogenous Trk B ligand activation.

Related Experiment Videos

  • Examined the effects of TrkB IgG on LTP and LTD expression at postnatal day 17 (P17) and P23, a period of peak brain-derived neurotrophic factor (BDNF) expression.

    • Main Results:

    • Trk B activation was essential for the long-term maintenance (>30 min) of LTP and LTP after LTD at P17.
    • A higher concentration of TrkB IgG was required to impair LTP at P23, suggesting a developmental shift in Trk B dependency.
    • Blockade of Trk B ligands did not affect the amplitude or duration of LTD at either developmental stage.

    Conclusions:

    • Endogenous Trk B ligands are necessary for the expression of LTP, but not LTD, during a critical window of postnatal visual cortex development.
    • These findings underscore the specific role of Trk B signaling in promoting LTP maintenance, contributing to the refinement of synaptic connections in the developing brain.