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Long-term outcome of cognition and functional health after cerebral venous sinus thrombosis

S F de Bruijn1, M Budde, S Teunisse

  • 1Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands. The Cerebral Venous Sinus Thrombosis Study Group.

Neurology
|April 13, 2000
PubMed

Insights

Long-term outcomes after sinus thrombosis may be poor, with many survivors experiencing cognitive impairments and functional limitations. Anticoagulant treatment did not significantly alter these unfavorable results.

Area of Science:

  • Neurology
  • Vascular Medicine

Background:

  • Cerebral venous sinus thrombosis (CVST) is a rare but serious condition.
  • Previous studies suggest good recovery for many patients, but long-term data are limited.

Purpose of the Study:

  • To assess the long-term cognitive and functional health outcomes in patients surviving cerebral venous sinus thrombosis (CVST).
  • To evaluate the impact of anticoagulant treatment versus placebo on these outcomes.

Main Methods:

  • A randomized trial comparing anticoagulant treatment to placebo was conducted.
  • Cognition and functional health were assessed in surviving patients one year or more post-enrollment.

Main Results:

  • Of 47 evaluable patients, 35% exhibited cognitive impairments.
  • 6% were functionally dependent, and 40% faced lifestyle restrictions.
  • 40% could not return to their previous economic activity level.
  • Outcomes were not significantly improved by anticoagulant treatment.

Conclusions:

  • Long-term outcomes following cerebral venous sinus thrombosis (CVST) may be less favorable than previously reported.
  • Anticoagulant therapy did not demonstrate a significant influence on patient recovery in this cohort.

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