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Long-term outcome of cognition and functional health after cerebral venous sinus thrombosis
S F de Bruijn1, M Budde, S Teunisse
1Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands. The Cerebral Venous Sinus Thrombosis Study Group.
Insights
Long-term outcomes after sinus thrombosis may be poor, with many survivors experiencing cognitive impairments and functional limitations. Anticoagulant treatment did not significantly alter these unfavorable results.
Area of Science:
- Neurology
- Vascular Medicine
Background:
- Cerebral venous sinus thrombosis (CVST) is a rare but serious condition.
- Previous studies suggest good recovery for many patients, but long-term data are limited.
Purpose of the Study:
- To assess the long-term cognitive and functional health outcomes in patients surviving cerebral venous sinus thrombosis (CVST).
- To evaluate the impact of anticoagulant treatment versus placebo on these outcomes.
Main Methods:
- A randomized trial comparing anticoagulant treatment to placebo was conducted.
- Cognition and functional health were assessed in surviving patients one year or more post-enrollment.
Main Results:
- Of 47 evaluable patients, 35% exhibited cognitive impairments.
- 6% were functionally dependent, and 40% faced lifestyle restrictions.
- 40% could not return to their previous economic activity level.
- Outcomes were not significantly improved by anticoagulant treatment.
Conclusions:
- Long-term outcomes following cerebral venous sinus thrombosis (CVST) may be less favorable than previously reported.
- Anticoagulant therapy did not demonstrate a significant influence on patient recovery in this cohort.
Abstract:
The authors examined cognition and functional health of 57 patients with sinus thrombosis 1 year or more after enrollment in a randomized trial of anticoagulant treatment or placebo. Eight patients died and two declined participation. Of the remaining 47 patients, 16 (35%) had cognitive impairments, 3 (6%) were dependent, 19 (40%) had symptoms that led to restrictions in lifestyle, and 19 (40%) could not resume their previous level of economic activity. Outcome after sinus thrombosis may be less favorable than reported previously, and was not significantly influenced by treatment.