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Concurrent modulation of anxiety and memory.

P M Wall1, C Messier

  • 1School of Psychology, University of Ottawa, Vanier: Room 215, Ottawa, Canada. pmwall@uottawa.ca

Behavioural Brain Research
|April 14, 2000
PubMed
Summary
This summary is machine-generated.

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Blocking kappa receptors in the infralimbic cortex of mice with norBNI induced anxiety and impaired spontaneous working memory. This suggests kappa receptor modulation influences anxiety and memory processing.

Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Pharmacology

Background:

  • The ventromedial prefrontal cortex (vmPFC) is implicated in spontaneous working memory and anxiety-related behaviors.
  • Kappa(1) agonists in the infralimbic (IL) area of the vmPFC reduce anxiety and enhance working memory.
  • The specificity of these effects to IL kappa receptors requires further investigation.

Purpose of the Study:

  • To determine if kappa receptor antagonism in the IL cortex influences anxiety and spontaneous memory.
  • To investigate the hypothesis that kappa antagonist norBNI in the IL cortex produces effects opposite to kappa agonists.

Main Methods:

  • Mice received microinjections of the kappa antagonist norBNI (or vehicle) in the IL cortex.
  • Behavioral tests included the elevated plus-maze (anxiety, reference memory) and Y-maze (spontaneous working memory).

Related Experiment Videos

  • Testing occurred over two weeks, with varying orders for anxiety and memory assessments.

    • Main Results:

    • NorBNI administration dose-dependently induced anxiogenic behavior and reduced transfer latencies in the elevated plus-maze.
    • Spontaneous working memory was disrupted by norBNI in the Y-maze, irrespective of testing order.
    • Anxiogenic effects persisted in the second elevated plus-maze trial 24 hours after initial testing.

    Conclusions:

    • Modulation of kappa receptors in the IL cortex significantly impacts anxiety induction and spontaneous working memory.
    • These findings support the role of kappa receptors in the IL cortex for regulating anxiety and memory.
    • Immediate memory processing may influence the induction of anxiety-related behaviors.