Related Experiment Videos
Incidence of multiple sclerosis in Dijon, France: a population-based ascertainment
Abstract:
Incidence of multiple sclerosis (MS) was prospectively determined within the population of the city of Dijon (94,000 inhabitants under 60 years old) at 47 degrees northern latitude, in Burgundy, France. All the incident cases were diagnosed according to the criteria of Poser, associated to the study of cerebrospinal fluid, evoked potentials and cerebral magnetic resonance imaging. Diagnosis was assessed in all the cases by a neurologist working either in the University Hospital (four neurologists) or in private offices (seven neurologists). The ascertainment was performed on a full 5-year period, from 1993 to 1997. Twenty-one cases were diagnosed in the population of 94,000 inhabitants, with an incidence of 6.1/100,000/year in women, 3.3/100,000/year in men and 4.3/100,000/year in both sexes. The sex-ratio female/male was 2.5. Our data are similar to those of the literature, in particular in countries around the Burgundy area. Our data allow evaluation of the burden of MS in our area and allow evaluation of the changes of incidence in the future.
Insights
This study determined the incidence of multiple sclerosis (MS) in Dijon, France, finding an overall rate of 4.3 per 100,000 person-years. The incidence was higher in women than men, with a female-to-male ratio of 2.5.
Area of Science:
- Epidemiology
- Neurology
- Public Health
Background:
- Multiple sclerosis (MS) is a chronic neurological disease with variable incidence rates globally.
- Accurate incidence data is crucial for understanding disease burden and planning healthcare resources.
Purpose of the Study:
- To prospectively determine the incidence of multiple sclerosis (MS) in Dijon, France.
- To establish the epidemiological characteristics of MS in this specific geographic region.
- To provide baseline data for future incidence trend analysis.
Main Methods:
- Prospective population-based study conducted over a 5-year period (1993-1997) in Dijon, France.
- Inclusion of all incident cases diagnosed by neurologists using Poser criteria.
- Diagnostic confirmation supported by cerebrospinal fluid analysis, evoked potentials, and magnetic resonance imaging.
Main Results:
- A total of 21 incident cases of MS were identified in a population of 94,000 inhabitants under 60 years old.
- The overall incidence rate was 4.3 per 100,000 person-years.
- Incidence rates were 6.1/100,000/year in women and 3.3/100,000/year in men, yielding a sex-ratio of 2.5 (female/male).
Conclusions:
- The incidence of MS in Dijon is comparable to other regions in similar latitudes.
- The findings provide valuable insights into the epidemiological burden of MS in Burgundy, France.
- This data serves as a foundation for monitoring future changes in MS incidence.