Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Development of neonatal Th1/Th2 function.

B Adkins1

  • 1Department of Microbiology and Immunology, University of Miami Medical School, FL 33136, USA. radkins@mednet.med.miami.edu

International Reviews of Immunology
|April 14, 2000
PubMed
Summary

Newborn animals often exhibit weak T cell immunity, making them vulnerable to infections. Research suggests this Th2-dominant response in neonates, rather than an inability to develop Th1 function, is a key area of study in developmental immunology.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thymic and extrathymic contributions to T helper cell function in murine neonates.

Haematologica reports·2011
Same author

Choroid plexus selectively accumulates T-lymphocytes in normal controls and after peripheral immune activation.

Journal of neuroimmunology·2005
Same author

CD4+ and CD8+ cells accumulate in the brains of acquired immunodeficiency syndrome patients with human immunodeficiency virus encephalitis.

Journal of neurovirology·2003
Same author

Toxin levels in serum correlate with the development of staphylococcal scalded skin syndrome in a murine model.

Infection and immunity·2001
Same author

The generation of Th memory in neonates versus adults: prolonged primary Th2 effector function and impaired development of Th1 memory effector function in murine neonates.

Journal of immunology (Baltimore, Md. : 1950)·2001
Same author

Early block in maturation is associated with thymic involution in mammary tumor-bearing mice.

Journal of immunology (Baltimore, Md. : 1950)·2000

Area of Science:

  • Immunology
  • Developmental Biology
  • Neonatal Health

Background:

  • Neonates exhibit immature immune systems, leading to increased susceptibility to pathogens.
  • Historically, poor T helper 1 (Th1) responses were thought to cause neonatal vulnerability.
  • Recent findings indicate Th1 responses can be achieved in newborns, challenging older theories.

Purpose of the Study:

  • To investigate the immunological "default" in newborn animals.
  • To understand the reasons behind the prevalent Th2-dominant immune responses in neonates.
  • To explore factors contributing to Th2 skewing in early life immunity.

Main Methods:

  • Comparative immunology studies in neonatal and adult animal models.
  • Analysis of T cell responses, specifically Th1 and Th2 differentiation.
  • Investigation of intrinsic cellular and extrinsic environmental factors influencing immune development.

Main Results:

  • Newborn animals frequently develop Th2-dominant immune responses.
  • Evidence suggests Th1 function is achievable in neonates under specific conditions.
  • Both cell-intrinsic and environmental factors are implicated in neonatal Th2 skewing.

Conclusions:

  • The "default" immune response in neonates is often Th2-dominant, not necessarily due to an intrinsic inability to mount Th1 responses.
  • Understanding the mechanisms of Th2 skewing is crucial for addressing neonatal infectious diseases.
  • Further research is needed to elucidate the interplay of cellular and environmental factors in neonatal immune development.

Related Experiment Videos