Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genotype and phenotype resistance: an overview.

G Angarano1, L Monno

  • 1Clinic of Infectious Diseases, University of Bari, Italy. g.angarano@clininf.uniba.it

Journal of Biological Regulators and Homeostatic Agents
|April 14, 2000
PubMed
Summary

Drug resistance significantly impacts antiretroviral therapy success for HIV-1. Understanding resistance patterns and utilizing resistance testing aids in selecting effective HIV treatments and managing therapy failure.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peculiar clinical presentation of COVID-19 and predictors of mortality in the elderly: A multicentre retrospective cohort study.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases·2021
Same author

Maternal caesarean section infection (MACSI) in Sierra Leone: a case-control study.

Epidemiology and infection·2020
Same author

Splenic abscesses as a first manifestation of Crohn's disease: a case report.

BMC gastroenterology·2019
Same author

Prevalence of acquired resistance mutations in a large cohort of perinatally infected HIV-1 patients.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2019
Same author

Cerebrospinal fluid compartmentalization of HIV-1 and correlation with plasma viral load and blood-brain barrier damage.

Infection·2019
Same author

Optimising management of patients with hepatitis C virus in the age of direct-acting antivirals: results of a Delphi consensus.

European review for medical and pharmacological sciences·2018

Area of Science:

  • Virology
  • Infectious Diseases
  • Pharmacology

Background:

  • Drug resistance is a primary cause of antiretroviral therapy failure in HIV-1 treatment.
  • Human immunodeficiency virus type 1 (HIV-1) exhibits rapid replication and error-prone reverse transcriptase, leading to diverse resistant strains.
  • Understanding resistance and cross-resistance is crucial for effective HIV treatment strategies.

Purpose of the Study:

  • To review the benefits and drawbacks of current drug resistance assays for HIV.
  • To explore the mechanisms and patterns of drug resistance and cross-resistance in HIV-1.
  • To highlight the role of resistance testing in guiding HIV therapy selection and management.

Main Methods:

  • Review of existing literature on HIV drug resistance assays.
  • Analysis of resistance and cross-resistance mechanisms and patterns.
  • Evaluation of the clinical utility of genotypic and phenotypic resistance testing.

Main Results:

  • Resistance assays have varying advantages and disadvantages.
  • Preliminary data suggests resistance testing can guide initial therapy, explain treatment failures, and inform subsequent treatment choices.
  • Specific resistance and cross-resistance patterns emerge due to viral evolution.

Conclusions:

  • Resistance testing plays a vital role in optimizing antiretroviral therapy for HIV-infected individuals.
  • Further research and integration of resistance testing into routine care may improve treatment outcomes.
  • Knowledge of resistance mechanisms is key to combating treatment failure.

Related Experiment Videos