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Systemic Therapy for Invasive Bladder Cancer.

Javle1, Raghavan

  • 1Division of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

Cancer Control : Journal of the Moffitt Cancer Center
|November 1, 1996
PubMed
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Systemic chemotherapy, particularly cisplatin-based combinations, offers the most effective treatment for advanced bladder cancer. Further research is ongoing to improve outcomes for localized and metastatic bladder cancer patients.

Area of Science:

  • Oncology
  • Urology

Background:

  • Bladder cancer is a prevalent malignancy in Western countries.
  • Around 10,000 US patients annually present with invasive bladder cancer.
  • Many patients progress from superficial to invasive bladder cancer.

Purpose of the Study:

  • To review systemic treatment options for localized and metastatic bladder cancer.
  • To outline approaches for managing various stages of bladder cancer.

Main Methods:

  • Literature review on systemic treatments for bladder cancer.
  • Inclusion of authors' clinical experience in treatment strategies.

Main Results:

  • Cisplatin-based combination chemotherapy is the most effective systemic treatment for advanced bladder cancer.

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  • Few patients achieve a cure with current systemic therapies.
  • Ongoing trials investigate neoadjuvant, adjuvant, and concurrent chemoradiation for improved outcomes.

    • Conclusions:

    • Combining systemic chemotherapy with definitive local therapy may benefit locally advanced bladder cancer.
    • Optimal treatment schedules and proven survival benefits require further establishment.