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Sporadic acute hepatitis E in the united kingdom: an underdiagnosed phenomenon?
R McCrudden1, S O'Connell, T Farrant
1Division of Cell and Molecular Medicine, D Level South Block Mail Point 811, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK. prm@soton.ac.uk
Background:
Hepatitis E (HEV) is the primary cause of enterically transmitted non-A non-B hepatitis worldwide. Case reports of HEV in individuals in the United Kingdom relate to travel to endemic areas or contact with individuals who have visited these areas.
Case Reports:
Four individuals presented with acute hepatitis to a hepatology clinic in a teaching hospital. Serology confirmed acute hepatitis E in all four. Investigation by the Communicable Disease Control Department established no links between the cases, no travel to an endemic area, and no contacts.
Conclusion:
Contrary to current belief, community acquired hepatitis E virus infection occurs sporadically in the United Kingdom and should be considered as a cause of seronegative hepatitis.
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