Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Progressive optic nerve cupping and neural rim decrease in a patient with bilateral autosomal dominant optic nerve

M Moore1, D Salles, L M Jampol

  • 1Department of Ophthalmology, Northwestern University Medical School, Chicago, Illinois, USA.

American Journal of Ophthalmology
|April 15, 2000
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

NF-κB-dependent DNA damage-signaling differentially regulates DNA double-strand break repair mechanisms in immature and mature human hematopoietic cells.

Leukemia·2015
Same author

Hypotony after glaucoma filtration surgery: mechanisms and incidence.

Journal of glaucoma·2009
Same author

LLL-3, a STAT3 inhibitor, represses BCR-ABL-positive cell proliferation, activates apoptosis and improves the effects of Imatinib mesylate.

Cancer chemotherapy and pharmacology·2009
Same author

Antioxidants and zinc to prevent progression of age-related macular degeneration.

JAMA·2003
Same author

Management of eyes with both idiopathic macular hole and choroidal neovascularization.

Retina (Philadelphia, Pa.)·2002
Same author

Antioxidants and zinc to prevent progression of age-related macular degeneration.

JAMA·2002

This study documents progressive optic nerve damage in a patient with autosomal dominant optic nerve colobomas and normal eye pressure. Findings suggest insights into normal tension glaucoma progression.

Area of Science:

  • Ophthalmology
  • Genetics
  • Optic Nerve Disorders

Background:

  • Autosomal dominant optic nerve colobomas are rare congenital optic nerve anomalies.
  • Normal tension glaucoma (NTG) is characterized by optic nerve damage and visual field loss with normal intraocular pressure.

Observation:

  • A case study of a 27-year-old woman with bilateral autosomal dominant optic nerve colobomas was reviewed over 13 years.
  • Ophthalmology records, fundus photographs, and visual fields were analyzed for changes in optic nerve appearance.

Findings:

  • The patient exhibited progressive optic nerve cupping and neural rim decrease despite consistently normal intraocular pressures.
  • Visual field testing over five years revealed abnormalities but no significant progression.

Related Experiment Videos

Implications:

  • This case may offer insights into the mechanisms of optic nerve cupping seen in normal tension glaucoma.
  • Close monitoring of patients with optic disk colobomas is crucial for detecting optic nerve changes and visual field loss.