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Updated: Oct 17, 2026

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16
Published on: July 15, 2019
Monofocal outer retinitis associated with hand, foot, and mouth disease caused by coxsackievirus
P Haamann1, L Kessel, M Larsen
1Department of Ophthalmology, Herlev Hospital, University of Copenhagen, Herlev, Denmark. haamann@dadlnet.dk
Purpose:
To report symptoms and signs from an otherwise healthy man with photopsia and monofocal outer retinitis occurring 3 days after the onset of hand, foot, and mouth disease.
Method:
Case report.
Results:
Ophthalmic examination revealed a single circumscribed area of pigment epithelial mottling in the left eye and a corresponding nonarcuate absolute scotoma. Fluorescein angiography demonstrated attenuation of the retinal pigment epithelium. Serologic tests at 1 month after the onset disclosed serum antibody to enterovirus.
Conclusion:
The close association between the cutaneous eruption and the onset of visual symptoms suggests that the retinal lesion was caused by coxsackievirus infection.
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