Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Parameter uncertainty and variability in evaluative fate and exposure models.

E G Hertwich1, T E McKone, W S Pease

  • 1Energy & Resources Group, UC Berkeley, CA 94720-3050, USA.

Risk Analysis : an Official Publication of the Society for Risk Analysis
|April 15, 2000
PubMed
Summary

Uncertainty in human toxicity potential calculations is significant, often spanning one to two orders of magnitude. Chemical-specific parameters, particularly half-lives, are the primary drivers of this variance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultrafine, fine, and black carbon particle concentrations in California child-care facilities.

Indoor air·2017
Same author

Model framework for integrating multiple exposure pathways to chemicals in household cleaning products.

Indoor air·2016
Same author

VOC exposures in California early childhood education environments.

Indoor air·2016
Same author

Formaldehyde and acetaldehyde exposure and risk characterization in California early childhood education environments.

Indoor air·2016
Same author

Indoor inhalation intake fractions of fine particulate matter: review of influencing factors.

Indoor air·2015
Same author

Estimated effect of ventilation and filtration on chronic health risks in U.S. offices, schools, and retail stores.

Indoor air·2015

Area of Science:

  • Environmental Science
  • Toxicology
  • Risk Assessment

Background:

  • Human toxicity potential (HTP) is crucial for evaluating toxic emissions in life cycle assessments and toxics release inventories.
  • HTP relies on potential dose calculations and toxicity factors.

Purpose of the Study:

  • To evaluate the variance in potential dose calculations for HTP.
  • To identify sources of uncertainty, including chemical-specific parameters, exposure factors, and landscape parameters.

Main Methods:

  • Assessed the potential dose for 236 chemicals.
  • Grouped chemicals by dominant exposure route.
  • Conducted Monte Carlo analysis for representative chemicals in each group.

Main Results:

Related Experiment Videos

  • Variance in potential dose calculations is typically one to two orders of magnitude.
  • Point estimates for potential dose span ten orders of magnitude across chemicals.
  • Chemical-specific parameters, especially half-lives, are the main contributors to variance.

Conclusions:

  • Understanding uncertainty in HTP is vital for decision-making robustness.
  • Identifying uncertainty sources allows for targeted efforts to reduce it.
  • Exposure factors can be important for indirect exposure routes, while landscape characteristics have minor impact.