Effect of binders on anti hypertensive drugs

Tablets of antihypertensive drugs, Indapamide, Methyldopa and Clonidine have been prepared and their physico-chemical properties were determined. The effect of various binders viz. starch, acacia, sodium carboxymethyl cellulose (sod. CMC), gelatin and lactose on the properties of these tablets were studied. Formulations of tablets of indapamide, methyldopa and clonidine prepared in combination with acacia, lactose and sod. CMC, respectively result in the best flow properties, minimum percentage fines, low angle of repose and compressibility. The tablets prepared from these granules possess all quality features including a good dissolution profile. Gelatin, sod. CMC and starch have less effective granule formation leading to poor quality of tablets in case of Indapamide, Methyldopa and Clonidine, respectively.