[Duodenogastric reflux in humans]

Human duodenogastric reflux (DGR) was comprehensively studied via measurement of gastric juice bile acid levels, manometric, endoscopic and X-ray study in health and benign gastrointestinal diseases and during exercise. DRG is shown to fall in the physiological events that have a biologically determined circadian rhythm. There was an association of DGR with gastric secretion. The "refluctant dilution effect" was established which along with elimination provides a relative constancy of the concentrations of bile ACIDS FROM 0.025 TO 0.422 NG/ML. DGR regulation is effected by the coordinated motor and evacuatory performance of the gastroduodenal junction and duodenum which is described as a lock two-way system. It is concluded that DGR is involved in the formation of the internal gastric environment and hence plays a role in gastric digestion. The findings may be used in studies of the physiology of digestion and in clinical practice.