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Updated: Jul 20, 2026
05:19
Surgical Models of Gastroesophageal Reflux with Mice
Published on: August 25, 2015
[Duodenogastric reflux in humans]
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk
|April 15, 2000
Summary
Human duodenogastric reflux (DGR) exhibits a circadian rhythm and influences gastric digestion. Its regulation involves a coordinated gastroduodenal system, maintaining bile acid concentration for digestive health.
Area of Science:
- Gastroenterology
- Human Physiology
- Digestive System Function
Background:
- Duodenogastric reflux (DGR) is a physiological event with potential implications for gastric function.
- Understanding DGR's role in digestion and its regulation is crucial for gastrointestinal health.
Purpose of the Study:
- To comprehensively investigate human duodenogastric reflux (DGR).
- To elucidate the physiological regulation and digestive role of DGR.
Main Methods:
- Measurement of gastric juice bile acid levels.
- Manometric, endoscopic, and X-ray studies in healthy individuals and patients with benign gastrointestinal diseases.
- Assessment during exercise.
Main Results:
- DGR demonstrates a circadian rhythm, aligning with physiological events.
- A significant association was found between DGR and gastric secretion.
- The "refluctant dilution effect" was established, maintaining relative bile acid constancy (0.025–0.422 NG/ML).
- DGR regulation is governed by a coordinated gastroduodenal "lock two-way system".
Conclusions:
- DGR is integral to forming the internal gastric environment.
- DGR plays a significant role in gastric digestion.
- Findings have implications for digestive physiology research and clinical practice.
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