Related Experiment Video
Updated: Oct 17, 2026

Bringing the Clinic Home: An At-Home Multi-Modal Data Collection Ecosystem to Support Adaptive Deep Brain Stimulation
Published on: July 14, 2023
Functional appliances: mode of action and clinical use
1Department of Orthodontics, John Radcliffe Hospital, Oxford.
Abstract:
Functional appliances are frequently used in the treatment of Class II division 1 malocclusions, either in isolation or, more commonly, before a course of fixed appliance therapy. Extensive speculation and investigation into the precise mode of action of these appliances has recently focused on their growth-restraining effect on the maxilla, their growth-enhancing effect on the mandible and dentoalveolar and soft tissue effects. The different types of functional appliances are described in this article, with emphasis placed on practitioners adopting a component approach to design. A checklist is provided to aid identification of the more common problems occurring during treatment.
Related Concept Videos
Direct-Acting Cholinergic Agonists: Therapeutic Uses
Operant Conditioning Intervention
In operant conditioning, behaviors that are...
Adrenergic Agonists: Therapeutic Classification
Vasopressor or pressor agents: They increase blood pressure and function as cardiac stimulants. Examples include endogenous catecholamines (norepinephrine and dopamine) and synthetic agents (phenylephrine).
Bronchodilators: β2-agonists can relax bronchial muscles and widen airways. They are commonly used for treating obstructive pulmonary...
Cholinergic Antagonists: Therapeutic Uses
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal secretions in common...
Indirect-Acting Cholinergic Agonists: Pharmacological Actions
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
Adrenergic Agonists: Therapeutic Uses
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and anaphylaxis:...