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Tissue engineering of the bladder.

G Falke1, J Caffaratti, A Atala

  • 1Department of Urology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

World Journal of Urology
|April 15, 2000
PubMed
Summary
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Gastrointestinal tissue for bladder reconstruction causes complications. Acellular collagen matrices and autologous cell transplantation show promise for bladder regeneration, offering a potential alternative to traditional methods.

Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Urology

Background:

  • Gastrointestinal tissue use in cystoplasty leads to complications like infection, metabolic issues, and malignancy.
  • Current methods for bladder augmentation and replacement necessitate exploring alternative, safer approaches.

Purpose of the Study:

  • To investigate acellular collagen-based matrices as scaffolds for bladder regeneration.
  • To explore the potential of engineered functional bladder tissue using selective cell transplantation.

Main Methods:

  • Utilizing autologous cells to avoid immune rejection.
  • Obtaining host tissue biopsies, dissociating and expanding cells in vitro.
  • Reattaching expanded cells to a matrix for subsequent implantation.

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Main Results:

  • Demonstrated successful engineering of functional bladder tissue.
  • Showcased the potential of acellular collagen matrices in bladder regeneration research.

Conclusions:

  • Acellular collagen matrices and autologous cell transplantation represent a promising alternative for bladder regeneration.
  • This approach minimizes complications associated with gastrointestinal tissue use in cystoplasty.