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Myoblast therapy for stress urinary incontinence and bladder dysfunction.
T Yokoyama1, J Huard, M B Chancellor
1Division of Urologic Surgery, University of Pittsburgh School of Medicine, Pennsylvania, USA.
World Journal of Urology
|April 15, 2000
Summary
This study explores using muscle-derived cells (myoblasts) for tissue engineering and gene therapy to treat urinary incontinence and bladder dysfunction. Myoblast-mediated gene transfer shows promise for urological applications.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Urology
Background:
- Tissue engineering and gene therapy offer promising future applications.
- Stress urinary incontinence and bladder dysfunction are significant clinical challenges.
Purpose of the Study:
- Investigate the use of myoblasts for treating stress urinary incontinence and bladder dysfunction.
- Explore the application of myoblast-mediated ex vivo gene transfer in urology.
Main Methods:
- Utilizing myogenic or muscle-derived cells.
- Applying tissue engineering principles.
- Implementing cell-mediated gene therapy techniques.
Main Results:
- Myoblast-based approaches show potential for improving treatments.
- Ex vivo gene transfer using myoblasts is a viable strategy for urological applications.
Conclusions:
- Myogenic cells are suitable for tissue engineering and cell-mediated gene therapy.
- This approach holds promise for advancing urological treatments.