Related Experiment Video
Updated: Aug 19, 2026

Visualizing Neuroblast Cytokinesis During C. elegans Embryogenesis
Published on: March 12, 2014
The Caenorhabditis elegans APC-related gene apr-1 is required for epithelial cell migration and Hox gene expression
E F Hoier1, W A Mohler, S K Kim
1Division of Cancer Research, Department of Pathology, University of Zürich, CH-8091 Zürich, Switzerland.
Abstract:
Inactivation of the Caenorhabditis elegans APC-related gene (apr-1) has pointed at two separate functions of apr-1. First, apr-1 is required for the migration of epithelial cells during morphogenesis of the embryo. In this process, APR-1 may act in a Cadherin/alpha-Catenin/beta-Catenin complex as a component of adherens junctions. Second, apr-1 is required for Hox gene expression, most likely by positively regulating the activity of the Wingless signaling pathway. During embryogenesis, apr-1 is required for the expression of ceh-13 labial in anterior seam and muscle cells and during larval development, apr-1 is necessary for the expression of lin-39 deformed in the vulval precursor cells. Thus, APR-1 may positively regulate the activity of the beta-Catenin/Armadillo-related proteins HMP-2 in migrating epithelial cells and BAR-1 in the vulval precursor cells.
More Related Videos
12:15The C. elegans Intestine As a Model for Intercellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis at the Single-cell Level: Labeling by Antibody Staining, RNAi Loss-of-function Analysis and Imaging
Published on: October 3, 2017
08:01Computational Analysis of the Caenorhabditis elegans Germline to Study the Distribution of Nuclei, Proteins, and the Cytoskeleton
Published on: April 19, 2018
Related Concept Videos
Hedgehog Signaling Pathway
Non-Canonical Wnt Signaling Pathways
Anaphase Promoting Complex
Cancer Cell Migration through Invadopodia
Cadherins in Tissue Organization
Cell Sorting During Development
Cell sorting plays an...
Role Of Notch Signalling In Intestinal Stem Cell Renewal
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...