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Clock and induction model for somitogenesis.

S Schnell1, P K Maini

  • 1Centre for Mathematical Biology, Mathematical Institute, Oxford, United Kingdom. schnell@maths.ox.ac.uk

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|April 15, 2000
PubMed
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A new model explains somitogenesis, the process of forming body segments (somites). It describes a novel signal wave pattern observed in the presomitic mesoderm, resolving long-standing developmental biology questions.

Area of Science:

  • Developmental Biology
  • Cellular and Molecular Biology
  • Biophysics

Background:

  • Somitogenesis, the formation of body segments (somites), remains a significant challenge in developmental biology.
  • Recent experiments reveal a novel pattern formation mechanism involving a signal wave in the presomitic mesoderm.
  • Existing theoretical models struggle to explain the observed signal behavior during somite formation.

Purpose of the Study:

  • To propose a new theoretical model for somitogenesis.
  • To account for the recently observed signal wave pattern during somite formation.
  • To reconcile experimental findings with theoretical explanations in developmental biology.

Main Methods:

  • Development of a novel theoretical model for somitogenesis.

Related Experiment Videos

  • Mathematical modeling of pattern formation during embryonic development.
  • Comparison of model predictions with experimental observations of signal dynamics.

    • Main Results:

    • The proposed model successfully explains the observed signal wave sweeping and narrowing during somitogenesis.
    • The model accounts for the signal's residual localization in the posterior half of newly formed somites.
    • The model is consistent with prior experimental data on somitogenesis.

    Conclusions:

    • The new model provides a robust framework for understanding the complex process of somitogenesis.
    • This work offers a potential explanation for the dynamic signal behavior observed in the presomitic mesoderm.
    • The findings contribute to resolving a major unresolved problem in developmental biology.