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Oxidative stress after lung resection therapy: A pilot study.

E C Lases1, V A Duurkens, W B Gerritsen

  • 1Department of Clinical Chemistry, St. Antonius Hospital, Nieuwegein, The Netherlands.

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Oxidative stress markers, including hydrogen peroxide (H2O2) and malondialdehyde (MDA), were elevated after lung surgery. These findings suggest oxidative stress occurs following pulmonary resection.

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Area of Science:

  • Biomedical research
  • Thoracic surgery
  • Oxidative stress markers

Background:

  • Pulmonary resection, including lobectomy and pneumonectomy, is a significant surgical procedure.
  • The occurrence and impact of oxidative stress post-pulmonary resection require further investigation.

Purpose of the Study:

  • To determine if oxidative stress occurs after lobectomy and pneumonectomy.
  • To assess the potential of oxidative stress markers in diagnosing and predicting postoperative complications.

Main Methods:

  • Prospective study involving 28 lung carcinoma patients undergoing thoracotomy.
  • Measurement of exhaled hydrogen peroxide (H2O2) in breath condensate.
  • Quantification of urinary malondialdehyde (MDA) levels using high-performance liquid chromatography.

Main Results:

  • Elevated levels of H2O2 and MDA were observed in patients who underwent lobectomy compared to pneumonectomy.
  • A significant positive correlation was identified between H2O2 and MDA levels.

Conclusions:

  • The study supports the hypothesis that oxidative stress is present following pulmonary resection.
  • Oxidative stress markers may play a role in understanding the postoperative course after lung surgery.