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Influence of age on the multifocal electroretinography
N Mohidin1, M K Yap, R J Jacobs
1Department of Optometry and Vision Science, University of Auckland, New Zealand.
Summary
Age impacts retinal function, with older adults showing reduced multifocal electroretinogram responses in central vision. This age-related decline in the central retina may be linked to photoreceptor loss.
Area of Science:
- Ophthalmology
- Neuroscience
- Physiology
Background:
- The multifocal electroretinogram (ERG) assesses retinal function.
- Age-related changes in visual system function are well-documented.
- Understanding these changes is crucial for diagnosing and managing visual impairments.
Purpose of the Study:
- To investigate the influence of age on the amplitude density of the multifocal electroretinogram (ERG).
- To determine if age affects retinal function in healthy individuals across different age groups.
Main Methods:
- 90 healthy subjects aged 18-52 years were divided into three age groups: 18-22, 33-37, and 48-52 years.
- Multifocal ERG amplitude density was measured.
- Statistical analysis included ANOVA and post hoc tests to compare age groups and retinal regions.
Main Results:
- No significant differences in overall retinal amplitude density were found between age groups.
- Significant differences in ERG responses were observed between different retinal eccentricities and age groups.
- Responses from the central retina and the second ring were significantly lower in the 48-52 year olds compared to younger groups.
Conclusions:
- Age significantly affects multifocal ERG responses, particularly in the central retina.
- The observed decline in central retinal function with age may be associated with a reduction in photoreceptor number.
- No significant gender-based differences in amplitude density were detected.