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Updated: Aug 10, 2026

Investigations on the Ga(III) Complex of EOB-DTPA and Its 68Ga Radiolabeled Analogue
11:22

Investigations on the Ga(III) Complex of EOB-DTPA and Its 68Ga Radiolabeled Analogue

Published on: August 17, 2016

111In-DTPA-D-Phe1-octreotide binding and somatostatin receptor subtypes in thyroid tumors

E B Forssell-Aronsson1, O Nilsson, S A Bejegård

  • 1Department of Radiation Physics, Sahlgrenska University Hospital, Göteborg University, Sweden.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|April 18, 2000
PubMed
Abstract

Insights

Radiolabeled octreotide shows promise for thyroid tumor therapy. High tumor-to-blood ratios were observed, indicating potential for treating somatostatin receptor-positive thyroid cancers.

Area of Science:

  • Nuclear Medicine
  • Oncology
  • Endocrinology

Background:

  • Thyroid tumors are a diverse group of neoplasms.
  • Somatostatin analogs are used in diagnosis and therapy of neuroendocrine tumors.
  • Radiolabeled somatostatin analogs offer targeted delivery of radiation.

Purpose of the Study:

  • To evaluate the therapeutic potential of radiolabeled somatostatin analog octreotide for thyroid tumors.
  • To assess the uptake of radiolabeled octreotide in various types of thyroid tumors.
  • To correlate octreotide uptake with somatostatin receptor expression in thyroid tissues.

Main Methods:

  • Inclusion of tissues from 68 patients with various thyroid tumors.
  • Intravenous injection of 111In-labeled octreotide and measurement of 111In activity in tumors and blood.
  • Analysis of somatostatin receptor subtype expression (sstr1-5) using Northern blot and ribonuclease protection assay (RPA).

Main Results:

  • High tumor-to-blood ratios (T/B) were observed for medullary thyroid carcinoma, follicular adenoma, Hurthle cell adenoma, Hurthle cell carcinoma, and papillary carcinoma.
  • T/B values in tumors were significantly higher than in normal thyroid tissue.
  • While sstr2 expression varied by Northern blot, RPA detected sstr2 in all tumor types, suggesting broad applicability.

Conclusions:

  • Radiolabeled octreotide demonstrates significant tumor uptake in various thyroid tumor types.
  • High tumor-to-blood ratios suggest potential for targeted radiation therapy.
  • Further investigation is warranted for the clinical application of radiolabeled octreotide in treating somatostatin receptor-positive thyroid tumors.

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