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Chronic myelomonocytic leukemia with t(1;3)(p36;q21) and a synchronous gastric cancer

S Fujisawa1, H Harano, E Yamazaki

  • 1Department of Hematology and Immunology, Yokosuka Municipal Hospital, Yokohama City University School of Medicine, Japan.

The American Journal of the Medical Sciences
|April 18, 2000
PubMed

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...