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Manganese intoxication

J W Lee1

  • 1Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul.

Archives of Neurology
|April 18, 2000
PubMed

Insights

Excess manganese causes irreversible nervous system damage, leading to manganism and complex neurological symptoms like dystonic parkinsonism, particularly with environmental exposure. This review covers historical cases, pathology, and treatments for manganese intoxication.

Area of Science:

  • Neuroscience
  • Toxicology
  • Environmental Health

Background:

  • Manganese is an essential trace element, acting as a cofactor in numerous human enzymatic reactions.
  • However, excessive manganese exposure can lead to severe, irreversible neurological damage.

Observation:

  • Manganism, though rare, presents with complex nervous system symptoms.
  • Environmental exposure is a significant risk factor for manganese intoxication.
  • Manganese is a recognized cause of dystonic parkinsonism.

Findings:

  • This article reviews historical clinical manifestations of manganese intoxication.
  • It details the pathological changes associated with excessive manganese exposure.
  • The review also discusses historical attempts at therapeutic interventions for manganese toxicity.

Implications:

  • Understanding historical cases of manganism is crucial for diagnosing and managing current environmental exposures.
  • Recognizing manganese-induced dystonic parkinsonism aids in differential diagnosis of movement disorders.
  • Historical data informs ongoing research into the neurotoxic mechanisms and potential treatments for manganese intoxication.

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