Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Manganese intoxication.

J W Lee1

  • 1Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul.

Archives of Neurology
|April 18, 2000
PubMed
Summary
This summary is machine-generated.

Excess manganese causes irreversible nervous system damage, leading to manganism and complex neurological symptoms like dystonic parkinsonism, particularly with environmental exposure. This review covers historical cases, pathology, and treatments for manganese intoxication.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Features of the metabolic syndrome after childhood craniopharyngioma.

The Journal of clinical endocrinology and metabolism·2004
Same author

Diffusion-weighted MRI and ADC mapping in FK506 neurotoxicity.

The British journal of radiology·2004
Same author

Genetic analysis of the LKB1/STK11 gene in hepatocellular carcinomas.

European journal of cancer (Oxford, England : 1990)·2003
Same author

Effect of gamma irradiation on the survival of pathogens in kwamegi, a traditional Korean semidried seafood.

Journal of food protection·2003
Same author

Quantitation of motexafin lutetium in human plasma by liquid chromatography-tandem mass spectrometry and inductively coupled plasma-atomic emission spectroscopy.

AAPS pharmSci·2003
Same author

BRAF mutations in non-Hodgkin's lymphoma.

British journal of cancer·2003
Same journal

Incorrect Table Entries and Word.

Archives of neurology·2016
Same journal

IDEAL for CCSVI Research-Reply.

Archives of neurology·2013
Same journal

Atlas of Inherited Metabolic Diseases, 3rd ed.

Archives of neurology·2013
Same journal

Error in byline: in heterogeneity of coenzyme q10 deficiency: patient study and literature review.

Archives of neurology·2013
Same journal

This month in archives of neurology.

Archives of neurology·2013
Same journal

About this journal.

Archives of neurology·2013
See all related articles

Area of Science:

  • Neuroscience
  • Toxicology
  • Environmental Health

Background:

  • Manganese is an essential trace element, acting as a cofactor in numerous human enzymatic reactions.
  • However, excessive manganese exposure can lead to severe, irreversible neurological damage.

Observation:

  • Manganism, though rare, presents with complex nervous system symptoms.
  • Environmental exposure is a significant risk factor for manganese intoxication.
  • Manganese is a recognized cause of dystonic parkinsonism.

Findings:

  • This article reviews historical clinical manifestations of manganese intoxication.
  • It details the pathological changes associated with excessive manganese exposure.
  • The review also discusses historical attempts at therapeutic interventions for manganese toxicity.

Related Experiment Videos

Implications:

  • Understanding historical cases of manganism is crucial for diagnosing and managing current environmental exposures.
  • Recognizing manganese-induced dystonic parkinsonism aids in differential diagnosis of movement disorders.
  • Historical data informs ongoing research into the neurotoxic mechanisms and potential treatments for manganese intoxication.