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Bactericidal/permeability-increasing protein prevents mucosal damage in an experimental rat model of chronic otitis
M J Nell1, H K Koerten, J J Grote
1Department of Otorhinolaryngology, Leiden University Medical Center, Leiden, The Netherlands. M.J.Nell@lumc.nl
Infection and Immunity
|April 18, 2000
Abstract:
In this study, the efficacy of bactericidal/permeability-increasing protein (BPI) was assessed in a rat model of chronic otitis media with effusion. BPI injection prevented disturbance of the mucociliary clearance system of the middle ear. Hence, it is postulated that BPI can be a new therapy for chronic otitis media with effusion.