Related Experiment Video
Updated: Aug 2, 2026

09:27
Functional Complementation Analysis (FCA): A Laboratory Exercise Designed and Implemented to Supplement the Teaching of Biochemical Pathways
Published on: June 24, 2016
Characterization of ferrochelatase (hemH) mutations in Haemophilus influenzae
S Schlör1, M Herbert, M Rodenburg
1Zentrum für Infektionsforschung, Universität Würzburg, 97070 Würzburg, Germany.
Infection and Immunity
|April 18, 2000
Abstract:
Haemophilus influenzae lacks most of the biosynthetic enzymes for hemin synthesis. However, the organism has retained ferrochelatase activity, which we identified to be encoded by a hemH-homologous gene. In this report we characterize the growth physiology conferred by hemH mutations under infection and laboratory conditions.

