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Related Experiment Videos

Fate and function of the ventral ectodermal ridge during mouse tail development.

D C Goldman1, G R Martin, P P Tam

  • 1Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143-0452, USA.

Development (Cambridge, England)
|April 19, 2000
PubMed
Summary

The ventral ectodermal ridge (VER) in mouse embryos is crucial for tail development, providing signals essential for somitogenesis. This structure regulates bone morphogenetic protein (BMP) activity, influencing tail growth and patterning.

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Area of Science:

  • Developmental Biology
  • Embryology
  • Molecular Biology

Background:

  • Tail development in mouse embryos involves complex signaling pathways.
  • The ventral ectodermal ridge (VER) is a potential signaling center for tail development.

Purpose of the Study:

  • To investigate the role of the VER in mouse tail development.
  • To identify signaling molecules and cellular mechanisms controlled by the VER.

Main Methods:

  • Surgical ablation of the VER in mouse embryo tail explants.
  • In vitro culture of tail explants.
  • Dye labeling experiments for cell migration studies.
  • In situ hybridization for gene expression analysis.

Main Results:

Related Experiment Videos

  • VER ablation impaired tail somitogenesis, indicating its essential signaling role.
  • Cells within the VER migrate anteriorly and colonize the ventral ectoderm.
  • FGF17 and BMP2 are expressed in the VER.
  • VER signaling is required for noggin expression in the tail ventral mesoderm, suggesting BMP pathway regulation.

Conclusions:

  • The VER is a critical signaling center for mouse tail development.
  • VER-derived signals regulate somitogenesis and BMP activity.
  • Cellular migration from the VER contributes to ventral ectoderm patterning.