Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Calcium ions as extracellular, first messengers.

D Riccardi1

  • 1University of Manchester, School of Biological Sciences, United Kingdom. RICCARDI@fs1.scg.man.ac.uk

Zeitschrift Fur Kardiologie
|April 19, 2000
PubMed
Summary

Extracellular calcium concentration ([Ca2+]o) is vital and tightly regulated by a homeostatic system involving the calcium-sensing receptor (CaR). This review explores CaR

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First Measurement of Time-Dependent CP Violation in the Flavor-Changing Neutral-Current Decay B^{0}→K_{S}^{0}μ^{+}μ^{-}.

Physical review letters·2026
Same author

Measurement of the Top-Quark Production Cross Section and Charge Asymmetry at LHCb.

Physical review letters·2026
Same author

Searches for B^{0}→K^{+}π^{-}τ^{+}τ^{-} and B_{s}^{0}→K^{+}K^{-}τ^{+}τ^{-} Decays.

Physical review letters·2026
Same author

First Evidence of the B_{s}^{0}→K^{-}π^{+}γ Decay.

Physical review letters·2026
Same author

Precision Measurement of CP Violation and Branching Fractions in B^{±}→K_{S}^{0}h^{±} (h=π, K) Decays and Search for the Rare Decay B_{c}^{±}→K_{S}^{0}K^{±}.

Physical review letters·2026
Same author

First Observation of the B[over ¯]_{s}^{0}→Λ_{c}^{+}Λ[over ¯]_{c}^{-} Decay and Evidence for the B[over ¯]^{0}→Λ_{c}^{+}Λ[over ¯]_{c}^{-} Decay.

Physical review letters·2026

Area of Science:

  • Biochemistry
  • Physiology
  • Cell Biology

Background:

  • Extracellular calcium concentration ([Ca2+]o) is critical for essential physiological processes, including bone formation and blood clotting.
  • Mammalian species maintain strict control over [Ca2+]o through a complex homeostatic system involving the parathyroid glands, kidneys, and bone.
  • The extracellular calcium-sensing receptor (CaR) is a key regulator within this system, influencing parathyroid hormone secretion, renal calcium excretion, and bone remodeling.

Purpose of the Study:

  • To review the discovery of the calcium-sensing receptor (CaR) as a novel class of ion-sensing receptors.
  • To discuss the mechanisms of CaR-effector coupling.
  • To elucidate the roles of CaR both within and beyond the calcium (Ca2+) homeostasis system.

Main Methods:

  • Literature review of CaR discovery and function.
  • Analysis of CaR presence in various organs.
  • Examination of CaR's role in mineral ion metabolism and other physiological processes.

Main Results:

  • The CaR was initially identified in bovine parathyroid glands.
  • CaR expression has since been found in numerous organs beyond those directly involved in calcium homeostasis, such as the brain, stomach, eye, and skin.
  • The CaR plays a significant role in regulating calcium homeostasis and has potential roles in other physiological systems.

Conclusions:

  • The CaR is a crucial component of calcium homeostasis.
  • The widespread distribution of CaR suggests broader physiological functions beyond mineral ion regulation.
  • Further research is needed to fully understand the diverse roles of CaR in various tissues and cellular processes.

Related Experiment Videos