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Published on: October 12, 2017

Lipoprotein(a) status in coronary heart disease

M A Khan1, A Baseer

  • 1Department of Biochemistry, Jinnah Postgraduate Medical Centre, Karachi.

JPMA. the Journal of the Pakistan Medical Association
|April 19, 2000
PubMed

Insights

Patients with coronary heart disease (CHD) have significantly higher levels of lipoprotein(a) [Lp(a)] and other lipids. Elevated Lp(a) is crucial for assessing CHD risk and understanding its role in atherosclerosis.

Area of Science:

  • Cardiovascular Medicine
  • Clinical Biochemistry
  • Lipidology

Background:

  • Coronary heart disease (CHD) is a major global health concern.
  • Lipid and lipoprotein profiles are key indicators in cardiovascular risk assessment.
  • Lipoprotein(a) [Lp(a)] is an emerging risk factor for atherosclerosis.

Purpose of the Study:

  • To compare lipid and lipoprotein levels, particularly Lp(a), between patients with CHD and control subjects.
  • To investigate the association between specific lipid parameters and the presence of CHD.
  • To evaluate the clinical significance of Lp(a) in the context of CHD.

Main Methods:

  • Serum samples were analyzed from 37 patients with CHD and 25 age-matched controls.
  • Measurements included total cholesterol, triglycerides, HDL-C, LDL-C, VLDL-C, apo A1, apo B, and Lp(a).
  • Statistical analysis was performed to compare levels between groups.

Main Results:

  • Significant differences (P < 0.001) were observed in lipid and apolipoprotein ratios between CHD patients and controls.
  • Lp(a) and several other lipid parameters were significantly elevated in CHD patients.
  • HDL-C and apo B levels were significantly lower in CHD patients (P < 0.001).

Conclusions:

  • Elevated Lp(a) levels are strongly associated with coronary heart disease.
  • Lp(a) plays a significant role in the process of atherogenesis.
  • Lp(a) should be considered a critical marker for assessing an individual's risk of developing CHD.
Abstract

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