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A new method for quality control of zinc pyritione pharmaceutical and cosmetic forms
P Zubata1, R Ceresole, M T Pizzorno
1Cátedra de Control de Calidad de Medicamentos, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.
Drug Development and Industrial Pharmacy
|April 19, 2000
Abstract:
A simple high-performance liquid chromatographic (HPLC) method was developed to determine zinc pyritione in pharmaceutical and cosmetic products. Reversed-phase chromatography was conducted using a C18 column with an isocratic mobile phase consisting of a suitable mixture of methanol, acetonitrile, and water (30:2.5:20). The effluent was monitored on a ultraviolet (UV) detector at 243 nm. The method was validated following International Conference on Harmonisation (ICH) suggestions and proved accurate, precise, and specific.