Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 15, 2026

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
09:46

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

Mechanisms of deep brain stimulation and future technical developments.

E B Montgomery1, K B Baker

  • 1Department of Neurology, Lerner Research Institute, Cleveland Clinic Foundation, OH 44195, USA.

Neurological Research
|April 19, 2000
PubMed
Summary

Deep brain stimulation (DBS) may work by regulating neuronal activity. Computer simulations suggest high-frequency, regular stimulation improves information transfer, potentially explaining DBS therapeutic effects in movement disorders.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Physiological changes in the pallidum in a progressive model of Parkinson's disease: Are oscillations enough?

Experimental neurology·2016
Same author

Modeling the motor striatum under Deep Brain Stimulation in normal and MPTP conditions.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2010
Same author

Modeling the effects of Deep Brain Stimulation on sensorimotor cortex in normal and MPTP conditions.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2010
Same author

Male and female Fmr1 knockout mice on C57 albino background exhibit spatial learning and memory impairments.

Genes, brain, and behavior·2010
Same author

Haplotypes and gene expression implicate the MAPT region for Parkinson disease: the GenePD Study.

Neurology·2008
Same author

Deep brain stimulation of the ventral internal capsule/ventral striatum for obsessive-compulsive disorder: worldwide experience.

Molecular psychiatry·2008

Area of Science:

  • Neuroscience
  • Computational Biology
  • Neurological Disorders

Background:

  • Deep brain stimulation (DBS) is a therapeutic intervention for movement disorders.
  • The precise mechanisms of DBS, particularly its inhibitory effects, remain under investigation.
  • Neuronal activity patterns are crucial for information processing in the brain.

Purpose of the Study:

  • To explore the mechanisms of deep brain stimulation (DBS) by modeling its effects on neuronal information transfer.
  • To investigate how different frequencies and regularity of neuronal activity influence information processing.
  • To correlate simulation findings with symptoms of neurological movement disorders.

Main Methods:

  • Computer simulations were employed to model information transfer between neurons.

More Related Videos

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
09:16

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

Related Experiment Videos

Last Updated: Jul 15, 2026

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
09:46

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
09:16

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

  • Simulations varied the frequency and regularity of target neuron activity, both spontaneous and stimulated.
  • The impact of these variations on information transfer efficiency was analyzed.

    • Main Results:

    • Most simulations indicated a loss of information transfer.
    • High-frequency and regular neuronal activity or stimulation minimized information loss.
    • Irregular neuronal activity was associated with reduced information transfer, potentially explaining movement disorder symptoms.
    • Stochastic resonance, an augmentation of information transfer, was observed, particularly with low-frequency activity.

    Conclusions:

    • Deep brain stimulation (DBS) may exert therapeutic effects by promoting high-frequency and regular neuronal firing patterns.
    • Irregular neuronal activity could underlie symptoms in conditions like Parkinson's disease, dystonia, and hemiballismus.
    • Low-frequency neuronal activity might contribute to involuntary movements such as tremor, potentially via stochastic resonance.