[Recent donation and clinical results of homograft tissue]

Between August 1995 and July 1999, we have experienced 14 donors for allografts (mean age: 39.8 +/- 15.8, M/F = 10/4, mean warm ischemic time: 359 minutes). Donated tissues were included 12 aortic valves and 12 pulmonary valves, respectively. Since February 1994, clinical diagnoses of 14 patients included 7 congenital heart disease, 5 infective heart disease, 1 artificial graft infection, and 1 thrombosed valve. There was no graft-transmitted disease. In congenital heart disease, 3 patients (HLHS: 1, Truncus: 1, TOF + PA: 1) died (early mortality, 42%) and 1 with TGA had residual conduit stenosis. However, in infective heart disease, all patients survived without recurrent infection and did not need reoperation (early mortality, 0%). Our clinical results of homograft implantation for infective heart disease were excellent, but more careful consideration will be needed for congenital heart disease in neonates and/or patients with poor preoperative condition.