Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cola drinks consumption and oesophagitis.

S Kapicioğlu1, A Baki, A Reis

  • 1Karadeniz Technical University, School of Medicine, Department of Internal Medicine, Trabzon, Turkey.

Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus
|April 19, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

At-home vs In-office Bleaching: An Updated Systematic Review and Meta-analysis.

Operative dentistry·2025
Same author

<i>ARID1B</i>-related disorder in 87 adults: Natural history and self-sustainability.

Genetics in medicine open·2024
Same author

Clinical performance of posterior restorations using a universal adhesive over moist and dry dentin: A 36-month double-blind split-mouth randomized clinical trial.

Journal of dentistry·2024
Same author

Demographic structure across all known populations of the rheophyte Dyckia brevifolia Baker (Bromeliaceae) in the Itajaí-Açu River, Southern Brazil.

Brazilian journal of biology = Revista brasleira de biologia·2024
Same author

Effect of silver diamine fluoride on the longevity of the bonding properties to caries-affected dentine.

Journal of dentistry·2024
Same author

Color Match of a Universal-shade Composite Resin for Restoration of Non-carious Cervical Lesions: An Equivalence Randomized Clinical Trial.

Operative dentistry·2023
Same journal

Identification of transient hiatal hernia on high-resolution manometry is associated with gastroesophageal reflux disease.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2026
Same journal

Screening for Barrett's esophagus and esophageal adenocarcinoma: recent advances and next steps.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2026
Same journal

Limited evidence cannot validate routine gastropexy for paraesophageal hernia repair.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2026
Same journal

CD39 and PD-L1 co-expression may serve as potential indicators for evaluating the efficacy of neoadjuvant immunotherapy in esophageal squamous cell carcinoma.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2026
Same journal

Diagnostic performance of postoperative endoscopy versus water-soluble esophagram in detecting anastomotic leak after esophagectomy.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2026
Same journal

Response to the correspondence on 'Limited Evidence Cannot Validate Routine Gastropexy for Paraesophageal Hernia Repair'.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2026
See all related articles

Cola consumption may impact esophageal health by promoting cell proliferation and regeneration, despite not causing visible damage in rats. Further research is needed to understand these effects on the esophageal mucosa.

Area of Science:

  • Gastroenterology
  • Cell Biology
  • Toxicology

Background:

  • Gastro-oesophageal reflux disease (GORD) can lead to esophageal epithelial changes if the refluxate is sufficiently acidic.
  • Cola drinks possess a highly acidic pH (around 2.5), raising questions about their potential impact on esophageal tissue.

Purpose of the Study:

  • To investigate the influence of cola consumption on the esophageal mucosa.
  • To analyze the interaction between cola intake and potential oesophagitis.
  • To assess the proliferative and regenerative effects of cola on esophageal tissue.

Main Methods:

  • Twenty rats were divided into two groups, receiving either saline (pH 7.0) or cola (pH 2.6) orally for 24 hours.
  • Esophageal tissues were examined macroscopically and histopathologically.

Related Experiment Videos

  • Flow cytometry was employed to analyze cell cycle phases and determine the proliferative-regenerative index (PI).

    • Main Results:

    • Histopathological analysis revealed no macroscopic or microscopic differences between the saline and cola groups.
    • Cell cycle analysis indicated significant differences: the cola group showed lower G0/G1 phase populations (p < 0.01) and significantly elevated S and PI phases (p < 0.01) compared to the control group.
    • The elevated PI in the cola group suggests a heightened regenerative response in the esophageal mucosa.

    Conclusions:

    • Cola consumption, despite not causing apparent histopathological damage, induces significant proliferative and regenerative effects on the esophageal mucosa in rats.
    • These effects may be a consequence of cola's irritant properties on the esophageal lining.
    • Further investigation is warranted to elucidate the long-term implications of these findings for esophageal health.