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Related Experiment Videos

Transient hyperphosphatasemia--where do we stand?

S Kutílek1, M Bayer

  • 1Department of Pediatrics, Charles University Faculty of Medicine, Prague.

The Turkish Journal of Pediatrics
|April 19, 2000
PubMed
Summary
This summary is machine-generated.

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Transient hyperphosphatasemia of infancy and early childhood (THI) is a benign condition in young children with temporary high alkaline phosphatase levels. Follow-up shows normal growth and bone density, indicating no long-term health issues.

Area of Science:

  • Pediatrics
  • Biochemistry
  • Endocrinology

Background:

  • Transient hyperphosphatasemia of infancy and early childhood (THI) involves temporary elevations in serum alkaline phosphatase (S-ALP) in children under five.
  • This condition presents without clinical or biochemical evidence of metabolic bone disease or liver dysfunction.
  • Over 400 cases have been reported, suggesting a notable, albeit transient, pediatric health phenomenon.

Purpose of the Study:

  • To summarize the characteristics, proposed etiologies, and clinical outcomes of THI.
  • To emphasize the benign nature of THI and guide against unnecessary diagnostic interventions.

Main Methods:

  • Review of existing literature and case reports on THI.
  • Analysis of clinical presentations, biochemical findings, and follow-up data of affected children.

Related Experiment Videos

Main Results:

  • THI is characterized by elevated S-ALP, primarily bone or liver isoforms, in children under five.
  • No common underlying disease is identified, though viral etiology and multifactorial pathogenesis are suggested.
  • Prospective follow-up confirms THI is benign, with normal growth and bone density.

Conclusions:

  • THI is a transient, benign condition in young children.
  • The pathogenesis is likely multifactorial, possibly involving viral triggers.
  • Children diagnosed with THI should not undergo extensive diagnostic workups due to the condition's favorable prognosis.