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Human leukocyte antigens in Turkish pediatric celiac patients
1Department of Pediatrics, Istanbul University Cerrahpaşa Faculty of Medicine.
Insights
This study found specific human leukocyte antigen (HLA) phenotypes, including HLA-A25(10), HLA-B8, and HLA-DQ2, are more common in Turkish children with celiac disease, indicating a higher risk. HLA-B4 showed a protective effect.
Area of Science:
- Immunogenetics
- Pediatric Gastroenterology
- Human Leukocyte Antigens
Background:
- Celiac disease is an autoimmune disorder triggered by gluten ingestion.
- Human Leukocyte Antigen (HLA) phenotypes are associated with celiac disease susceptibility.
- Understanding HLA frequencies in specific populations is crucial for disease research.
Purpose of the Study:
- To determine the frequency of specific HLA phenotypes in Turkish pediatric celiac disease patients.
- To investigate the association between HLA types and celiac disease risk in a Turkish cohort.
- To identify potential protective HLA alleles.
Main Methods:
- Serological analysis using micro lymphocytotoxic reaction to study HLA-A, -B, -DR, and -DQ.
- Comparison of HLA phenotype frequencies between 30 pediatric celiac disease patients and a control group.
- Risk assessment for specific HLA antigens in relation to celiac disease.
Main Results:
- HLA-A25(10), HLA-B8, HLA-DR18(3), and HLA-DQ2 were significantly more frequent in celiac patients.
- Children with HLA-B8 had a five-fold increased risk, and those with HLA-DQ2 had a nine-fold increased risk for celiac disease.
- HLA-B4 demonstrated a protective role against celiac disease.
Conclusions:
- Specific HLA phenotypes, notably HLA-A25(10), are prevalent in Turkish pediatric celiac disease patients.
- HLA-B8 and HLA-DQ2 are significant risk factors for celiac disease in this population.
- HLA-B4 may offer protection against celiac disease development.
Abstract:
With the aim to determine the frequency of human leukocyte antigen phenotypes of celiac disease in Turkey, thirty celiac patients fulfilling the European Society of Pediatric Gastroenterology and Nutrition criteria were included in the study. The mean age of the study population was 5.8 +/- 4.3 years and of the control subjects was 32.6 +/- 6.7 years. The human leukocyte antigens -A, -B, -DR and -DQ were studied serologically by micro lymphocytotoxic reaction. It was found that human leukocyte antigens A-25(10), -B8, -DR18(3) and -DQ2 were more significantly frequent in the celiac population than in the control group. Children with antigen -B8 showed a five times higher risk for celiac disease and those with antigen -DQ2 showed a nine times higher risk. It was determined that human leukocyte antigen -B4 had a protective role in celiac disease. The study suggests that the human leukocyte antigen -A25(10) is a phenotype particularly encountered in Turkish pediatric celiac patients.