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Glycopeptide-resistant Enterococcus faecium BM4416 is a VanD-type strain with an impaired D-Alanine:D-Alanine ligase
B Perichon1, B Casadewall, P Reynolds
1Unité des Agents Antibactériens, Institut Pasteur, 75724 Paris Cedex 15, France. brunoper@pasteur.fr
Antimicrobial Agents and Chemotherapy
|April 19, 2000
Abstract:
VanD-type Enterococcus faecium BM4416 was constitutively resistant to vancomycin and to teicoplanin by synthesis of peptidoglycan precursors ending in D-alanyl-D-lactate. Like E. faecium BM4339, the only VanD-type strain described so far, BM4416 produced an impaired D-alanine:D-alanine ligase. Unlike for BM4339, which had a 5-bp insertion in ddl, inactivation of the gene in BM4416 was due to insertion of IS19.