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Hepatitis C virus infection as an opportunistic disease in persons infected with human immunodeficiency virus

M S Sulkowski1, E E Mast, L B Seeff

  • 1Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. msulkows@jhmi.edu.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|April 20, 2000
PubMed

Insights

Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) coinfection is common and accelerates liver disease progression. New strategies are urgently needed to prevent HCV infection and manage liver disease in coinfected individuals.

Area of Science:

  • Virology
  • Hepatology
  • Infectious Diseases

Background:

  • Hepatitis C virus (HCV) causes chronic liver disease, cirrhosis, and liver cancer.
  • HCV and human immunodeficiency virus (HIV) coinfection is prevalent, affecting about one-third of US HIV-infected individuals.
  • HIV coinfection exacerbates HCV progression and increases hepatotoxicity risk from antiretroviral drugs.

Purpose of the Study:

  • To highlight the significance of HCV and HIV coinfection.
  • To underscore the accelerated liver disease progression in coinfected individuals.
  • To emphasize the urgent need for prevention and management strategies.

Main Methods:

  • Literature review on HCV and HIV epidemiology and pathogenesis.
  • Analysis of the impact of coinfection on disease progression.
  • Synthesis of current understanding of HCV/HIV interactions.

Main Results:

  • HIV coinfection is associated with higher HCV RNA levels.
  • HIV coinfection accelerates the progression of HCV-related liver disease.
  • HCV infection increases the risk of hepatotoxicity from HIV medications.

Conclusions:

  • Chronic HCV infection acts as an opportunistic disease in HIV-infected individuals.
  • Coinfection leads to increased incidence and accelerated natural history of HCV.
  • Urgent need for strategies to prevent HCV and manage liver disease in coinfected populations.

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