[Autoimmune diseases]

In most autoimmune diseases no specific cause can be identified. Autoimmune disorders are induced by a loss of tolerance where self cannot be differentiated from foreign. Infections can provoke autoimmune processes, e.g. rheumatic fever. The degree of severity and the extent of disease are influenced by environmental factors and genetic characteristics. The identification of antibodies can be helpful for diagnosis. Certain antibodies are associated with specific manifestations (e.g. Ro-antibodies). Often, however, antibodies are nonspecific. Despite considerable progress in treatment, cure is rare. Treatment of autoimmune diseases requires continuous consideration of clinical activity and necessity of medication.