Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serotonin discontinuation syndrome: does it really exist?

S Nuss1, C R Kincaid

  • 1Dept. of Medicine, Robert C. Byrd Health Sciences Center of West Virginia University, Morgantown, USA.

The West Virginia Medical Journal
|April 20, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nursing: an international perspective.

Nebraska nurse·2002
Same author

Synthesis of new fluidity-enhanced amphiphilic compounds for soluble protein two-dimensional crystallization purpose.

Chemistry and physics of lipids·2000
Same author

Self-assembly of soluble proteins on functionalized lipid layers: a tentative correlation between the fluidity properties of the lipid film and protein ordering.

Chemistry and physics of lipids·2000
Same author

Appalachian perspective on modifiable risk factors in coronary artery disease: how well are we doing?

Southern medical journal·1999
Same author

Maternal cell contamination in amniotic fluid samples as a consequence of the sampling technique.

Human genetics·1994

Stopping antidepressant medication can lead to withdrawal symptoms, known as antidepressant discontinuation syndrome. This review highlights the need for better guidelines on safely discontinuing selective serotonin reuptake inhibitors (SSRIs).

Area of Science:

  • Psychiatry
  • Pharmacology
  • Clinical Medicine

Background:

  • Current depression treatment guidelines predominantly address diagnosis and initiation of antidepressant therapy.
  • Limited guidance exists regarding the safe and effective discontinuation of antidepressant medications.
  • The widespread use of selective serotonin reuptake inhibitors (SSRIs) has increased attention on withdrawal effects.

Observation:

  • Two clinical cases illustrating antidepressant discontinuation syndrome are presented.
  • Literature review on SSRI withdrawal symptoms and management strategies is included.

Findings:

  • Abrupt cessation of SSRIs can precipitate a distinct discontinuation syndrome.
  • Symptoms may include flu-like sensations, insomnia, nausea, and sensory disturbances.

Related Experiment Videos

  • The syndrome underscores the importance of gradual tapering protocols.

    • Implications:

    • There is a critical need to develop comprehensive guidelines for antidepressant discontinuation.
    • Clinicians should be aware of potential discontinuation symptoms when managing patients on SSRIs.
    • Further research is warranted to optimize tapering strategies and minimize patient distress.