Prevalence of rubella virus in suspected cases of congenital infections

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M Ballal1, P G Shivananda

  • 1Department of Microbiology, Kasturba Medical College, Manipal.

Indian Journal of Pediatrics
|March 1, 1997
PubMed

Insights

Congenital rubella infection was detected in 15.2% of infants using IgM antibody tests. Common signs included congenital cataracts and enlarged liver/spleen in infected newborns.

Area of Science:

  • Pediatrics
  • Virology
  • Immunology

Background:

  • Congenital infections pose significant risks to newborns.
  • Rubella virus infection during pregnancy can lead to severe infant health issues.

Purpose of the Study:

  • To determine the prevalence of rubella specific IgM antibodies in infants suspected of congenital infections.
  • To identify common clinical manifestations associated with congenital rubella infection.

Main Methods:

  • A cohort of 342 infants with suspected congenital infections was analyzed.
  • Serum samples were tested for rubella specific IgM antibodies using microplate enzyme-linked immunosorbent assay (mu ELISA).

Main Results:

  • 52 out of 342 infants (15.2%) tested positive for rubella specific IgM antibodies.
  • The most frequent clinical signs observed in IgM-positive infants were bilateral congenital cataracts and hepatosplenomegaly.

Conclusions:

  • Congenital rubella infection is a notable concern in infants presenting with specific symptoms.
  • Early detection of rubella specific IgM antibodies is crucial for identifying infected infants and managing potential complications.

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