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Related Experiment Videos

Brainstem auditory evoked response in tuberculous meningitis.

R K Kapoor1, A Makharia, R Shukla

  • 1Department of Pediatrics, King George's Medical College, Lucknow, U.P., India.

Indian Journal of Pediatrics
|May 1, 1997
PubMed
Summary

Brainstem auditory evoked response (BAER) abnormalities are common in tuberculous meningitis (TBM), affecting over half of patients. Specific BAER changes correlate with disease severity, offering insights into neurological impact.

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Area of Science:

  • Neurology
  • Pediatrics
  • Infectious Diseases

Background:

  • Tuberculous meningitis (TBM) poses significant neurological risks in children.
  • Brainstem auditory evoked response (BAER) is a sensitive tool for assessing auditory pathway integrity.
  • Understanding BAER alterations in TBM is crucial for diagnosis and prognosis.

Purpose of the Study:

  • To determine the prevalence and patterns of BAER abnormalities in pediatric TBM.
  • To investigate correlations between BAER findings and clinical/laboratory parameters in TBM.
  • To assess the potential of BAER for monitoring disease progression and recovery.

Main Methods:

  • A case-control study involving 50 children with TBM and 50 healthy controls.
  • BAER testing was performed on all participants.

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  • Clinical data, including seizure activity, Glasgow Coma Scale (GCS), intracranial pressure (ICP), and TBM stage, were recorded.

    • Main Results:

    • Over 56% of TBM patients exhibited abnormal BAER findings.
    • The most common abnormality was prolonged latency and interval (32%), followed by prolonged latency (16%).
    • Abnormal BAER significantly correlated with seizures, GCS, ICP, and advanced TBM stage (III).

    Conclusions:

    • BAER abnormalities are prevalent in pediatric TBM, indicating widespread neurological dysfunction.
    • Specific BAER patterns correlate with clinical severity, suggesting its utility in TBM assessment.
    • Follow-up BAER showed potential for recovery in some patients, highlighting the dynamic nature of neurological involvement.