Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Medulloblastoma--a retrospective analysis.

B S Awasthy1, C Das Gupta, R Singh

  • 1Department of Radiotherapy, All India Institute of Medical Sciences, New Delhi.

Indian Journal of Pediatrics
|April 20, 2000
PubMed
Summary

Adjuvant chemotherapy significantly improved disease-free survival in medulloblastoma patients post-surgery and radiotherapy. Extent of surgical removal also impacted overall survival rates.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Utility of Sirolimus Eluting Balloons in the Setting of Chronic Limb Threatening Ischaemia in Asian Patients from Singapore - 12 Months Results of the PRISTINE Registry.

Cardiovascular and interventional radiology·2024
Same author

Spontaneous tumor regression mediated by human T cells in a humanized immune system mouse model.

Communications biology·2023
Same author

Is Substantial Lymphovascular Space Invasion Prognostic for Clinical Outcomes in Type II Endometrial Cancer?

Clinical oncology (Royal College of Radiologists (Great Britain))·2022
Same author

A tetra-nuclear nickel(II) complex, [Ni<sub>4</sub>(<i>L</i>)<sub>4</sub>](ClO<sub>4</sub>)<sub>4</sub>·C<sub>2</sub>H<sub>3</sub>N·2H<sub>2</sub>O, with an asymmetric Ni<sub>4</sub>O<sub>4</sub> open-cubane-like core.

Acta crystallographica. Section E, Crystallographic communications·2022
Same author

9-Arylimino noscapinoids as potent tubulin binding anticancer agent: chemical synthesis and cellular evaluation against breast tumour cells.

SAR and QSAR in environmental research·2021
Same author

Evolving multidisciplinary treatment of squamous cell carcinoma of the head and neck in India<sup>✰</sup>.

Cancer treatment and research communications·2020

Area of Science:

  • Neuro-oncology
  • Pediatric Oncology
  • Radiation Oncology

Background:

  • Medulloblastoma is a primary malignant brain tumor in children.
  • Treatment involves surgery, craniospinal irradiation, and chemotherapy.
  • Prognostic factors and outcomes require further investigation.

Purpose of the Study:

  • To evaluate outcomes in medulloblastoma patients treated with postoperative radiotherapy and chemotherapy.
  • To identify prognostic factors influencing survival in this patient cohort.

Main Methods:

  • Retrospective review of 45 medulloblastoma patients.
  • Analysis of treatment modalities: surgery, radiotherapy, and chemotherapy.
  • Assessment of overall and disease-free survival, and prognostic factors.

Related Experiment Videos

Main Results:

  • Median overall survival: 57 months; median disease-free survival: 31 months.
  • 3-year overall survival rate was 76%.
  • Adjuvant chemotherapy significantly improved disease-free survival (p=0.01).
  • Extent of surgery (complete vs. subtotal) significantly impacted overall survival (p=0.01).
  • Recurrence occurred in 11 patients, primarily in the posterior fossa.

Conclusions:

  • Postoperative radiotherapy with or without chemotherapy is a standard treatment for medulloblastoma.
  • Adjuvant chemotherapy is crucial for improving disease-free survival.
  • Surgical extent is a significant factor for overall survival.