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Treatment resistant smokers: a pilot study of nicotine nasal spray and inhaler
J R Hughes1, J A Grass, J L Pillitteri
1Department of Psychiatry, University of Vermont, Burlington 05401-1419, USA.
Journal of Addictive Diseases
|April 20, 2000
Abstract:
A growing proportion of smokers are those who have failed prior treatments for cessation. We tested the efficacy of nicotine nasal spray and nicotine inhaler in two uncontrolled, open-label studies of 19 and 20 smokers who had previously failed nicotine patch therapy. As in the three prior studies of treatment failures, 6 month abstinence rates were extremely low both with the nasal spray (0%) and the inhaler (5%). We discuss possible treatments for and methodological issues in researching treatment-resistant smokers.