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Familial arteriovenous malformations in siblings
T Kamiryo1, P K Nelson, A Bose
1Department of Radiology, Section of Interventional Neuroradiology, New York University Medical Center, New York, New York 10016, USA.
Surgical Neurology
|April 25, 2000
Summary
Two sisters with brain arteriovenous malformations (AVMs) were successfully treated. This rare familial AVM case highlights successful endovascular embolization and surgical resection for brain AVMs.
Area of Science:
- Neurology
- Neurosurgery
- Genetics
Background:
- Familial brain arteriovenous malformations (AVMs) are exceptionally rare conditions.
- This study details two sisters from the same family diagnosed with cerebral AVMs.
Observation:
- The elder sister presented with unilateral headaches suggestive of migraine.
- The younger sister experienced headaches triggered by physical activity.
- Both siblings were neurologically intact prior to intervention.
Findings:
- Diagnostic imaging, including MRI and angiography, confirmed the presence of AVMs in both sisters.
- Both underwent successful endovascular embolization followed by surgical resection.
- Post-treatment, both patients remained neurologically intact, with the elder sister experiencing a minor visual field defect.
Implications:
- This case underscores the possibility of familial AVM occurrence, though no specific genetic predisposition was identified.
- Successful combined endovascular and surgical treatment strategies are effective for familial brain AVMs.
- Further research may be warranted to explore potential genetic factors in rare familial AVM cases.