Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Celiac disease and TNF promoter polymorphisms.

E G de la Concha1, M Fernández-Arquero, P Vigil

  • 1Department of Immunology, San Carlos University Hospital, Madrid, Spain. egomezedela@hcsc.insalud.es

Human Immunology
|April 25, 2000
PubMed
Summary

Genetic susceptibility to celiac disease (CD) is linked to tumor necrosis factor (TNF) gene variations. The TNF-308A allele was significantly more frequent in CD patients, suggesting a role beyond HLA class II genes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Imaging a terahertz superfluid plasmon in a two-dimensional superconductor.

Nature·2026
Same author

Exploring the pangenome of Mycoplasma hyorhinis in search of potential virulence markers.

Scientific reports·2025
Same author

Superstability of micrometre jets surrounded by a polymeric shell.

Journal of applied crystallography·2025
Same author

Coastal current convergence structures in the Bay of Biscay from optimized high-frequency radar and satellite data.

The Science of the total environment·2024
Same author

Ultrafast electron localization and screening in a transition metal dichalcogenide.

Proceedings of the National Academy of Sciences of the United States of America·2023
Same author

Negative refraction in hyperbolic hetero-bicrystals.

Science (New York, N.Y.)·2023

Area of Science:

  • Genetics
  • Immunology
  • Gastroenterology

Background:

  • Genetic susceptibility to celiac disease (CD) has been linked to tumor necrosis factor (TNF) genes, but previous studies yielded contradictory results.
  • Existing research primarily used case-control designs, risking ethnic mismatching between patients and controls.

Purpose of the Study:

  • To investigate the association between TNF gene polymorphisms and celiac disease (CD) susceptibility.
  • To avoid ethnic bias by utilizing a family-based association design.

Main Methods:

  • Studied 71 celiac families using affected family-based controls (AFBAC).
  • Employed DNA-based methods to screen for HLA-DRB1, -DQA1, -DQB1 alleles, TNFalpha promoter polymorphisms, and TNFa/b microsatellites.
  • Analyzed the guanine-to-adenine polymorphism at position -308 of the TNFalpha gene promoter.

Related Experiment Videos

Main Results:

  • The TNF-308A allele was significantly increased in frequency within CD-associated haplotypes.
  • This association was independent of the known link between CD and HLA class II alleles (DRB1*0301, DQA1*0501, DQB1*0201).

Conclusions:

  • Results indicate that TNFalpha, or another gene in the HLA class III region, plays a role in celiac disease susceptibility.
  • This finding suggests an additional genetic factor contributing to CD beyond HLA class II associations.