Related Experiment Video
Updated: Aug 6, 2026
Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG
Published on: December 28, 2014
Remote effects of acute ischemic stroke: A xenon CT cerebral blood flow study
G Rubin1, E I Levy, A M Scarrow
1Department of Neurosurgery, University of Pittsburgh, Pittsburgh, PA, USA.
Objective:
The purpose of this study was to verify transhemispheric diaschisis in the early hours after an ischemic event.
Methods:
XeCT cerebral blood flow (CBF) studies within 8 h of stroke were studied in 23 patients. Mean CBF was evaluated in the ischemic area, contralateral hemisphere and ipsilateral cerebellum.
Results:
A severe CBF reduction was found in the ischemic area (mean 9 +/- 3 ml/100 g/min). The mean CBF in the unaffected hemisphere (33 +/- 10 ml/100 g/min) was 35% less compared to the normal mean value. CBF was decreased in the cerebellum ipsilateral to the stroke (mean 31 +/- 12 ml/100 g/min) suggesting a blood flow depression of the whole brain.
Conclusions:
During the initial hours of cerebral ischemia, the asymptomatic hemisphere demonstrated CBF depression that was part of the global flow reduction.
