Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Leukotropic herpesviruses in multiple sclerosis.

K A Hay1, R B Tenser

  • 1Department of Medicine (Neurology), Penn State University College of Medicine, Hershey, Pennsylvania, USA.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|April 25, 2000
PubMed
Summary

This study investigated human herpesvirus 6 (HHV-6) and Epstein Barr virus (EBV) DNA in multiple sclerosis (MS) patients. No association was found between HHV-6 in peripheral blood mononuclear leukocytes and MS.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Herpes zoster infection and postherpetic neuralgia.

Current neurology and neuroscience reports·2002
Same author

Inhibition of herpes simplex virus reactivation by dipyridamole.

Antimicrobial agents and chemotherapy·2001
Same author

Quantitative MRI in patients with clinically isolated syndromes suggestive of demyelination.

Neurology·1999
Same author

Herpes simplex virus latency after direct ganglion virus inoculation.

Journal of neurovirology·1998
Same author

Guillain-Barré syndrome after thalamotomy for tremor in MS.

Neurology·1998
Same author

Imaging and multiple sclerosis.

Annals of neurology·1998

Area of Science:

  • Neurovirology
  • Immunology
  • Molecular Biology

Background:

  • Human herpesvirus 6 (HHV-6) and Epstein Barr virus (EBV) are implicated in various neurological conditions.
  • Their potential role in the pathogenesis of multiple sclerosis (MS) remains an area of active research.

Purpose of the Study:

  • To determine the detection frequency of HHV-6 and EBV DNA in the peripheral blood mononuclear leukocytes (PBL) of MS patients and healthy controls.
  • To compare these findings with existing literature on HHV-6 detection in various biological samples from MS patients.

Main Methods:

  • DNA was isolated from PBL of MS patients and controls.
  • Polymerase chain reaction (PCR) techniques were employed for DNA amplification and detection of HHV-6 and EBV.
  • Detection rates were statistically analyzed and compared between groups.

Main Results:

  • EBV DNA was detected in 100% of both MS patients and controls.
  • HHV-6 DNA was detected in 7% of MS patients and 14% of controls.
  • The detection frequency of HHV-6 DNA in PBL did not show a significant difference between MS patients and controls.

Conclusions:

  • The findings do not support an association between HHV-6 detection in PBL and the presence of multiple sclerosis.
  • Further research may be needed to explore the role of other herpesviruses or different detection methods in MS pathogenesis.

Related Experiment Videos