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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Perinatal bacterial infection: an update

T J Yeagley1, J E Tolosa, V K Bhutani

  • 1Department of Obstetrics and Gynecology, Pennsylvania Hospital, Philadelphia 19016, USA. TJYTJY@POL.NET

Indian Journal of Pediatrics
|April 25, 2000
PubMed

Insights

Prompt management of perinatal infections, including bacterial infections of the uterus and amniotic fluid, improves outcomes. Early diagnosis and team-based care are key to preventing complications and potential premature delivery.

Area of Science:

  • Perinatology
  • Infectious Diseases
  • Obstetrics

Background:

  • Perinatal infections pose significant risks to both mother and fetus.
  • Bacterial infections can affect the uterus, placenta, membranes, amniotic fluid, and fetus near birth.

Purpose of the Study:

  • To review current trends in the evaluation and management of perinatal bacterial infections.
  • To highlight the importance of a multidisciplinary approach and diagnostic tools.

Main Methods:

  • Review of current literature on risk, incidence, pathophysiology, diagnosis, and management.
  • Discussion of interventional options: antibiotics, corticosteroids, fetal monitoring, and delivery.
  • Emphasis on clinical screening and amniotic fluid evaluation as diagnostic standards.

Main Results:

  • Cytokine analysis, such as IL-6, shows increasing importance in diagnosing infection and predicting complications like periventricular leukomalacia.
  • A team approach involving obstetricians and pediatricians is crucial for adequate evaluation and management.
  • Prompt recognition and management protocols can improve perinatal outcomes.

Conclusions:

  • Effective management of perinatal infections requires a structured approach and timely interventions.
  • Preventive measures and early diagnosis are vital to reduce the incidence of premature delivery due to infection.

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